个人信息简介

   姓名:马孟根

   职称:研究员

   研究领域:微生物学

   电子邮箱:mgen@sicau.edu.cn

   研究方向:能源微生物、环境微生物

   承担课程:

   本科生:农业微生物学

   硕士生:高级微生物学

   博士生:无

   研究生招生专业:

   硕士:微生物学、资源利用与植物保护

   博士:微生物学

 

  199409月—199807月,原四川畜牧兽医学院,畜牧兽医学士学位;

  199809月—200107月,beat365官方网站,预防兽医学硕士学位;

  200109月—200512月,四川大学,遗传学博士学位;

  200710月—201009月,美国新墨西哥州立大学和美国农业部,博士后。

  200107月—200710月,原四川省动物疫病监测诊断中心,助理研究员;

  201010月—201201月,四川省动物疫病预防控制中心,助理研究员;

  201202月—201312月,beat365官方网站资源环境学院,特聘教授;

  201401月—201503月,beat365官方网站资源环境学院生态环境研究所,研究员(破格晋升);

  201503月—今,beat365官方网站资源与地理信息技术研究所,研究员。

一、教学科研项目

(一)承担科研项目

  国家自然科学基金项目:酿酒酵母对木质纤维素水解关键抑制因子呋喃醛的适应性进化机理研究(2016.012019.12),主持。

  国家自然科学基金项目:大肠杆菌脂多糖转运关键蛋白LptFG的功能研究(2017.012019.12),参与。

  省部级科学研究项目:酿酒酵母木糖代谢途径的人工重构及优化改造(2013.012014.12),主持。

  省部级科学研究项目:纤维素燃料乙醇木糖代谢酿酒酵母菌的构建及应用研究(2014.012016.12),主持。

  省部级科学研究项目:纤维素燃料乙醇发酵酿酒酵母抑制物耐受基因工程菌的构建及应用研究(2020.012022.12),主持。

  校级科研项目:beat365官方网站人才引进科研启动经费(2012.022016.02.),主持。

(三) 指导学生创新创业与技能提升

  创新训练计划项目

秸秆水解抑制因子耐受热带假丝酵母菌株的选育及木糖醇发酵研究(2015,国家级)。

  科研兴趣培养项目

热带假丝酵母高温与乙醇耐受突变菌株的选育及发酵研究(2015,校级);

高温耐受热带假丝酵母突变菌株耐受性提高的机理研究(2018,校级);

热带假丝酵母中醛还原酶的基因的克隆及蛋白功能研究2018,校级)。

(四) 培养研究生获奖

李倩. 2019年度(硕士研究生)国家奖学金

肖迪凡. 2018年度校级优秀硕士毕业研究生

汪瀚宇. 2017年度校级优秀博士研究生

1.   Yidan Ouyang†, Qian Li†, Xiaolin Kuang, Hanyu Wang, Jinjian Wu, Ellen Ayepa, Huan Chen,Getachew Tafere Abrha, Zhengyue Zhang, Xi Li, Menggen Ma* (责任作者).YMR152W from Saccharomyces cerevisiae encoding a novel aldehyde reductase for detoxification of aldehydes derived from lignocellulosic biomass.Journal of Bioscience and Bioengineering, 2021,131(1):39-46. SCI收录)

2.   Xiaolin Kuang†, Yidan Ouyang†, Yaping Guo, Qian Li, Hanyu Wang, Getachew Tarere Abrha, Ellen Ayepa, Yunfu Gu, Xi Li, Qiang Chen, Menggen Ma* (责任作者). New insights into two yeast BDHs from the PDH subfamily as aldehyde reductases in context of detoxification of lignocellulosic aldehyde inhibitors. Applied Microbiology and Biotechnology, 2020, 104(15):66796692. (SCI收录)

3.   Hanyu Wang†, Qian Li†, Yuanyuan Peng†, Zhengyue Zhang†, Xiaolin Kuang, Xiangdong Hu, Ellen Ayepa, Xuebing Han, Getachew Tafere Abrha, Quanju Xiang, Xiumei Yu, Ke Zhao, Likou Zou, Yunfu Gu, Xi Li, Xiaoying Li, Qiang Chen, Xiaoping Zhang, Beidong Liu* (责任作者), Menggen Ma* (责任作者). Cellular analysis and comparative transcriptomics reveal the tolerance mechanisms of Candida tropicalis toward phenol. Frontiers in Microbiology, 2020, 11:544. (SCI收录)

4.   Xuebing Han†, Xiangdong Hu†, Chang Zhou†, Hanyu Wang, Qian Li, Yidan Ouyang, Xiaolin Kuang, Difan Xiao, Quanju Xiang, Xiumei Yu, Xi Li, Yunfu Gu, Ke Zhao, Qiang Chen, Menggen Ma* (责任作者). Cloning and functional characterization of xylitol dehydrogenase genes from Issatchenkia orientalis and Torulaspora delbrueckii. Journal of Bioscience and Bioengineering, 2020, 130(1):2935. (SCI收录)

5.   Xiangdong Hu†, Xuebing Han†, Lan Wu, Hanyu Wang, Yidan Ouyang, Qian Li, Xiaolin Kuang, Quanju Xiang, Xiumei Yu, Xi Li, Yunfu Gu, Ke Zhao, Qiang Chen, Menggen Ma* (责任作者). The open reading frame 02797 from Candida tropicalis encodes a novel NADH-dependent aldehyde reductase. Protein Expression and Purification, 2020, 171:105625. (SCI收录)

6.   Z. Lewis Liu* (责任作者) and Menggen Ma. Pathway-based signature transcriptional profiles as tolerance phenotypes for the adapted industrial yeast Saccharomyces cerevisiae resistant to furfural and HMF. Applied Microbiology and Biotechnology, 2020, 104(8):34733492. (SCI收录)

7.   Hanyu Wang†, Qian Li†, Zhengyue Zhang†, Chang Zhou, Ellen Ayepa, Getachew Tafere Abrha, Xuebing Han, Xiangdong Hu, Xiumei Yu, Quanju Xiang, Xi Li, Yunfu Gu, Ke Zhao, Chengcheng Xie, Qiang Chen, Menggen Ma* (责任作者). YKL107W from Saccharomyces cerevisiae encodes a novel aldehyde reductase for detoxification of acetaldehyde, glycolaldehyde, and furfural. Applied Microbiology and Biotechnology, 2019, 103(14):56995713. (SCI收录)

8.   Hanyu Wang†, Qian Li†, Xiaolin Kuang, Difan Xiao, Xuebing Han, Xiangdong Hu, Xi Li, Menggen Ma* (责任作者). Functions of aldehyde reductases from Saccharomyces cerevisiae in detoxification of aldehyde inhibitors and their biotechnological applications. Applied Microbiology and Biotechnology, 2018, 102(24):1043910456. (SCI收录)

9.   Hanyu Wang†, Yidan Ouyang†, Chang Zhou, Difan Xiao, Yaping Guo, Lan Wu, Xi Li, Yunfu Gu, Quanju Xiang, Ke Zhao, Xiumei Yu, Likou Zou, Menggen Ma* (责任作者). YKL071W from Saccharomyces cerevisiae encodes a novel aldehyde reductase for detoxification of glycolaldehyde and furfural derived from lignocellulose. Applied Microbiology and Biotechnology, 2017, 101(2324):84058418. (SCI收录)

10.  Xu Wang, Z. Lewis Liu*(责任作者), Xiaoping Zhang, Menggen Ma*(责任作者). A new source of resistance to 2-furaldehyde from Scheffersomyces (Pichia) stipitis for sustainable lignocellulose-to-biofuel conversion. Applied Microbiology and Biotechnology, 2017, 101(12):49814993. (SCI收录)

11.  Han-Yu Wang†, Di-Fan Xiao†, Chang Zhou, Lin-Lu Wang, Lan Wu, Ya-Ting Lu, Quan-Ju Xiang, Ke Zhao, Xi Li, Meng-Gen Ma*(责任作者). YLL056C from Saccharomyces cerevisiae encodes a novel protein with aldehyde reductase activity. Applied Microbiology and Biotechnology, 2017, 101(11):4507–4520. (SCI收录)

12.  Xu Wang, Menggen Ma*(责任作者), Z. Lewis Liu*(责任作者), Quanju Xiang, Xi Li, Na Liu, Xiaoping Zhang*(责任作者). GRE2 from Scheffersomyces stipitis as an aldehyde reductase contributes tolerance to aldehyde inhibitors derived from lignocellulosic biomass (来源于树干毕赤酵母的GRE2蛋白作为一种醛还原酶有助于该酵母菌对木质纤维素生物质衍生醛的耐受). Applied Microbiology and Biotechnology, 2016, 100(15):66716682. (SCI收录 IF=3.376)

13.  Xi Li†, Ruoheng Yang†, Menggen Ma*(责任作者), Xu Wang, Juan Tang, Xianxian Zhao, Xiaoping Zhang. A novel aldehyde reductase encoded by YML131W from Saccharomyces cerevisiae confers tolerance to furfural derived from lignocellulosic biomass conversion. Bioenergy Research, 2015, 8(1):119129. (SCI收录)

14.  Xianxian Zhao, Juan Tang, Xu Wang, Ruoheng Yang, Xiaoping Zhang, Yunfu Gu, Xi Li, Menggen Ma*(责任作者). YNL134C from Saccharomyces cerevisiae encodes a novel protein with aldehyde reductase activity for detoxification of furfural derived from lignocellulosic biomass. Yeast, 2015, 32(5):409422. (SCI收录)

15.  赵鲜仙, 周玚, 张思伟, 王琳璐, 路亚婷, 马孟根*(责任作者). ADH7启动子精细调控表达MSN2酿酒酵母菌株对糠醛耐受的研究. 微生物学通报, 2015, 42(10):19031911. (CSCD核心期刊)

16.  Menggen Ma†*(责任作者), Xu Wang†, Xiaoping Zhang, Xianxian Zhao. Alcohol dehydrogenases from Scheffersomyces stipitis involved in the detoxification of aldehyde inhibitors derived from lignocellulosic biomass conversion. Applied Microbiology and Biotechnology, 2013, 97(18):84118425. (SCI收录)

17.  Z. Lewis Liu*(责任作者), Jaewoong Moon, Menggen Ma, Patricia J. Slininger. New genotypes of industrial yeast Saccharomyces cerevisiae engineered with YXI and heterologous xylose transporters improve xylose utilization and ethanol production. Biocatalysis and Agricultural Biotechnology, 2013, 2(3):247254.

18.  Menggen Ma, Z. Lewis Liu*(责任作者), Jaewoong Moon. Genetic engineering of inhibitor-tolerant Saccharomyces cerevisiae for improved xylose utilization in ethanol production. Bioenergy Research, 2012, 5(2):459469. (SCI收录)

19.  Menggen Ma and Z. Lewis Liu*(责任作者). Comparative transcriptome profiling analyses during the lag phase uncover YAP1, PDR1, PDR3, RPN4, and HSF1 as key regulatory genes in genomic adaptation to the lignocellulose derived inhibitor HMF for Saccharomyces cerevisiae. BMC Genomics, 2010, 11: 660. (SCI收录)

20.  Menggen Ma and Z. Lewis Liu*(责任作者).  Quantitative transcription dynamic analysis reveals candidate genes and key regulators for ethanol tolerance in Saccharomyces cerevisiae. BMC Microbiology, 2010, 10:169. (SCI收录)

21.  Menggen Ma and Z. Lewis Liu*(责任作者). Mechanisms of ethanol tolerance in Saccharomyces cerevisiae. Applied Microbiology and Biotechnology, 2010, 87(3):829845. (SCI收录)

22.  Z. Lewis Liu*(责任作者), Menggen Ma, Mingzhou Song. Evolutionarily engineered ethanologenic yeast detoxifies lignocellulosic biomass conversion inhibitors by reprogrammed pathways. Molecular Genetics and Genomics, 2009, 282(3):233244. (SCI收录 IF=2.677)

23.  Z. Lewis Liu*(责任作者), Debra E. Palmquist, Menggen Ma, Jiangbo Liu, Nancy J. Alexander. Application of a master equation for quantitative mRNA analysis using qRT-PCR. Journal of Biotechnology, 2009, 143(1):1016. (SCI收录)

24.  Menggen Ma, Hongning Wang*(责任作者), Yong Yu, Dong Zhang, Shigui Liu. Detection of antimicrobial resistance genes of pathogenic Salmonella from swine with DNA microarray. Journal of Veterinary Diagnostic Investigation, 2007, 19(2):161167. (SCI收录)

三、出版教材及著作

  Menggen Ma and Z. Lewis Liu* (责任作者). Molecular mechanisms of ethanol tolerance in Saccharomyces cerevisiae (酿酒酵母乙醇耐受的分子机理). Microbial Stress Tolerance for Biofuels, Microbiology Monographs. Springer-Verlag Berlin Heidelberg, 2012, pp. 77115.

  Z. Lewis Liu* (责任作者), Menggen Ma, Michael A. Cotta. Reprogrammed Glucose Metabolic Pathways of Inhibitor-Tolerant Yeast (抑制物耐受酵母菌的葡萄糖代谢途径重调). Advances in Medicine and Biology (vol 9). NOVA Publishers, 2010, pp.159186.

  参编. 《最新猪繁殖障碍性疾病与防治》, 四川科学技术出版社, 2007, 成都.

  参编. 《禽呼吸系统疾病》, 中国农业出版社, 2002, 北京.

  参编.《饲料安全工作手册》, 中国农业科技出版社, 2001, 北京.

四、授权专利

  Zonglin L. Liu, jaewoong Moon, Patricia J. Slininger. Yeast strains and method for lignocellulose to ethanol production. US 9,102,931

  马孟根,周玚,李西,路亚婷,郭雅萍. 一种微生物培养发酵装置. ZL 2016 2 0155868.3

  马孟根,汪瀚宇,郭雅萍,肖迪凡,周玚,路亚婷,王琳璐. 一种酵母菌发酵装置. 2016 2 1174078.6

 

  陈惠, 王红宁, 吴琦, 邹立扣, 赵海霞, 韩学易, …, 马孟根. 新型饲用植酸酶和纤维素酶的创制及其应用. 2015年度四川省科技进步三等奖.(排名第9)

  王红宁, 刘书亮, 黄勇, 周生, 吴琦, 柳萍, 马孟根, 余勇, 吴祥辉. 猪、鸡病原菌耐药性检测及安全高效新兽药研发. 2004年度四川省科技进步一等奖.

  余勇, 石谦, 唐宗长, 王泽洲, 张东, 周明忠, 谢智明, 田楠, 杨松沛, 向顺禄, 叶成儒, 周哲学, 马孟根, 袁伟, 陈代平, 明智勇, 戴正瑞, 张履平, 罗长荣, 李春, 岳华. 四川省无规定动物疫病区建设及综合配套技术示范推广. 2003年度科技进步二等奖.

  马孟根. 2004年度防治高致病性禽流感工作先进个人. 四川省人民政府颁发.

  马孟根, 王红宁, 余勇, 李成忠, 张东, 羊云飞, 王泽洲, 刘世贵. 猪源致病性沙门氏菌耐药基因的检测研究.  2005年度中国畜牧兽医学会优秀论文奖.

 

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